Francis Lothian McNaughton M.D.,F.R.C.P. (C) (1906-1986)

Francis H. C. Crick (1916-2004).

Optimal strategic reasoning with McNaughton functions

Article history: Received 31 December 2013 Received in revised form 7 April 2014 Accepted 7 April 2014 Available online 24 April 2014

Dmd053405 1906..1913

Carbinol [4,49-(hydroxymethylene)dibenzonitrile] is the main phase 1 metabolite of letrozole, a nonsteroidal aromatase inhibitor used for endocrine therapy in postmenopausal breast cancer. We elucidated the contribution of UDP-glucuronosyltransferase (UGT) isoforms on the glucuronidation of carbinol. Identification of UGT isoforms was performed using a panel of recombinant human UGT enzymes. Ki...

Pierre Curie, 1859–1906

The year 2006 marked 100 years since the death of Pierre Curie. It is therefore appropriate that we remember his life and his work, which was cut short by his untimely death from an accident on the Pont Neuf, Paris, on April 19, 1906. He had already accomplished much during his life, both before the discovery of radium with Marie Curie, in work co-authored with his brother Jacques on piezoelect...

Francis Barr

influenza programme chief, reported an increase in the number of cluster cases reported recently, with the biggest being a family of five cases. There have been seven cluster cases in Vietnam, all within single families, most recently in the northern province of Haiphong. No relative has been proved to have passed the disease to another in these cases but, Horby said, " the onset dates could be...